Is Zepbound and Mounjaro the same thing? If not, how different are they? After all, both medications have the same main active ingredient and are made by one pharmaceutical company.
Yet, for branding and FDA approval purposes, these prescription drugs have separate names. Whether your concern is weight loss or type 2 diabetes, we’ll help you decide which one is right for you.
Our guide will compare the benefits, side effects, cost, and dosage of the two medications in the raging Zepbound vs. Mounjaro debate. Learn how to get them plus other worthy alternatives from Jack & Jill and other telehealth platforms.
What Are Zepbound and Mounjaro?
If you’re exploring weight loss or diabetes treatments, you may have come across Zepbound and Mounjaro. Though they have different names, they’re essentially the same medication created and produced by the company Eli Lilly.
Both use tirzepatide, a dual GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like-peptide-1) receptor agonist [1]. The difference? Branding.
Mounjaro was originally designed to manage type 2 diabetes, focusing on blood sugar control and potential weight loss. Zepbound, on the other hand, shines a spotlight directly on weight management. It positions itself as an alternative to Ozempic and Wegovy, prescription meds that help those battling obesity.
How Do They Work?
How does tirzepatide in Zepbound or Mounjaro actually work? The secret lies in its ability to mimic two key hormones: GIP and GLP-1 [1]. These hormones regulate blood sugar levels, slow digestion, and, best of all, tell your brain that you’re full.
When these hormones are present, they metaphorically flip a switch on your appetite and metabolism. By slowing down how quickly food moves through the digestive system, you’ll feel satisfied for longer periods. At the same time, it keeps blood sugar in check by improving insulin release when it’s needed most, like after a meal.
The result? A one-two punch that tackles both weight and blood sugar issues.
>>Explore Jack & Jill’s Mounjaro and Zepbound
Mounjaro vs. Zepbound Difference: How Do They Compare?
You may still be wondering, “Are Zepbound and Mounjaro the same thing?” To answer that question in detail, let’s talk about some of the most important aspects of any prescription drug: the ingredients, FDA approval status, and possible side effects.
Active Ingredients
When comparing the active Zepbound ingredients vs. Mounjaro, both rely on tirzepatide, as mentioned earlier. So, what’s the difference?
Whether you’re prescribed Mounjaro or Zepbound, you’re getting the same active ingredient working to control your cravings and boost your metabolism. The distinction lies in how the drugs are marketed and prescribed and their dosages.
FDA Approval
This is one of the few places where the paths of Mounjaro and Zepbound split. Mounjaro earned its FDA approval as a treatment for type 2 diabetes [2], with weight loss often seen as a “bonus” side effect—though weight loss is important in the management of diabetes. However, many people who have used this drug off-label report shedding extra pounds.
Zepbound, on the other hand, is the newer name on the market. This drug is also FDA-approved, except that it’s recommended for weight management for adults with obesity [3]. Because Zepbound is approved separately, healthcare providers can now prescribe it for weight loss alone rather than as a treatment for diabetes.
Zepbound vs. Mounjaro: Side Effects
Because both drugs have the same active ingredient, they have the same list of potential side effects. Common issues include:
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Nausea
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Diarrhea
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Constipation
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Decreased appetite
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Fatigue
There are also reports of more serious (though rare) side effects like pancreatitis or gallbladder issues. The risks of experiencing these issues are generally low, especially when you’re well-monitored by your doctor.
Who Might Benefit From Zepbound for Weight Loss?
Zepbound is approved by the FDA for weight management, and its main active ingredient has helped many tackle obesity head-on. But is it right for you? Let’s dig into who might see the most benefits from this medication.
If your BMI (Body Mass Index) lands in the obesity range, Zepbound could be a viable solution. It may also be a possible solution if you’re dealing with weight-related issues like high blood pressure, joint pain, or sleep apnea.
Its unique mechanism helps you lose fat while preserving muscle mass. So, it’s an option if you want to lower the number on the scale while maintaining your strength and energy.
It’s also worth considering if you’ve tried other weight loss methods without much success. Diet, exercise plans, and even other medications all have their limitations. Zepbound offers a targeted, science-backed approach that reduces appetite and regulates how your body processes food.
Yet, Zepbound isn’t just for people with obesity; it might also be prescribed for those on the cusp, especially if weight is significantly impacting their quality of life. And because it’s specifically FDA-approved for weight loss, you know it’s a focused treatment, not an off-label experiment.
>>Learn more about Zepbound and Mounjaro benefits
Who Might Benefit From Mounjaro for Weight Loss?
So, who’s the ideal candidate for Mounjaro? If you’re managing type 2 diabetes and want to lose weight as part of your health plan, Mounjaro might be an excellent option. Its dual action of regulating blood sugar and acting as an appetite suppressant tackles two challenges in one shot. Many patients report significant weight loss thanks to hunger curbing and slower digestion.
What if you don’t have diabetes but are still looking for effective weight-loss support? Mounjaro is sometimes prescribed “off-label” for weight management. This means some doctors recognize its effectiveness for weight loss, even though it’s not officially marketed for that purpose.
If you’re simply aiming to lose weight, asking your doctor about Zepbound would be a better idea.
Who Should Avoid Weight Loss Injections?
While weight loss injections like Zepbound and Mounjaro can offer incredible results for the right people, there are situations where they might not be the best choice.
If you have a history of medullary thyroid cancer or a genetic condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN2), these injections are a definite no. Why? Studies suggest a potential risk of thyroid tumors, so it’s better to play it safe and explore other weight loss methods [4].
Pregnant or planning to get pregnant? Weight loss injections should be off-limits for you, too. Your focus during pregnancy should be nourishment, not calorie reduction. Plus, there’s not much research on how these drugs might affect a developing baby.
If you’ve had issues with pancreatitis, that’s another red flag. Both Zepbound and Mounjaro can potentially irritate the pancreas, so if you’ve had inflammation there before, your doctor will likely tell you to stay away from them [4]. The same caution applies if you’ve experienced severe gastrointestinal issues. These drugs slow down digestion, which can make existing problems worse.
One other thing you should consider is your mindset. If you’re looking for a quick fix without considering long-term lifestyle changes, these injections might not meet your expectations. They’re designed to work alongside healthy habits, not replace them entirely.
>>Find out the current prices of Zepbound and Mounjaro at Jack & Jill
How Effective Are Zepbound and Mounjaro?
Both Zepbound and Mounjaro have the potential to be impressively effective when it comes to weight loss and diabetes management. In clinical trials, most people using Mounjaro for type 2 diabetes saw substantial weight loss as a benefit, up to 20% of their body weight [5].
And the best part? The benefits aren’t just about weight. Some people who tried these weight loss drugs report better control over their cravings, boosts in energy levels, and improved cholesterol levels, especially when they pair the medication with exercise and a reduced calorie diet.
That said, success depends on sticking with the program. That means weekly injections of these medications, as well as maintaining healthy habits like balanced eating and regular physical activity.
Mounjaro vs. Zepbound Dosing: How Are They Administered?
Zepbound and Mounjaro are administered with a small injection, so no pills or powders are needed. But don’t worry, the treatment isn’t complicated; both are designed to be simple and straightforward.
Zepbound Dosage
Zepbound is typically administered once a week through a subcutaneous injection (a scientific term for a shot under your skin). Most people inject it into their abdomen, thigh, or upper arm. Your healthcare provider will guide you on the exact dosage, but it usually starts low and is gradually increased based on your progress and how well your body tolerates it.
The idea is to ease your body into the treatment, minimizing potential side effects while letting the medication do its work. The weekly dose is also great for people with busy schedules.
Mounjaro Dosage
Like Zepbound, Mounjaro also follows a once-weekly injection routine. The starting dose is typically low, often 2.5 mg, to help your body adjust. Over time, your doctor may increase the dosage depending on your goals and how you’re responding.
Mounjaro comes in a pre-filled pen that’s easy to use, even if you’re squeamish about needles. You pick a day that works for you, inject it, and you’re good to go.
>>Check out Zepbound and Mounjaro prices at Jack & Jill
Zepbound vs. Mounjaro: Cost
Price obviously plays a major role. After all, these medications aren’t exactly cheap. Both are premium treatments for weight loss and diabetes, so understanding their cost and how insurance might help is crucial.
The producer of these drugs, Eli Lilly and Company, offers the listed price of these drugs per fill:
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Mounjaro: $1,079.77 [6]
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Zepbound: $1,086.37 [7]
However, the actual price you’ll pay per fill depends on a number of factors.
Are Zepbound and Mounjaro Covered by Insurance?
The short answer? It depends. Insurance coverage for Zepbound and Mounjaro can vary widely based on your provider, your plan, and the reason for the prescription.
If you’re using Mounjaro for type 2 diabetes (its FDA-approved purpose), many insurance plans are likely to cover at least part of the cost. But, if you’re prescribed the drug off-label for weight loss, coverage might be harder to secure.
Zepbound, on the other hand, is specifically approved for weight management. This should make insurance approval a little smoother, especially for patients with a BMI above 30 or weight-related health conditions. Still, even with coverage, co-pays or out-of-pocket expenses can add up, so it’s worth checking with your insurance provider to get the full picture.
If you’re not covered, you still have options. The manufacturer offers savings programs or discount cards, which can help reduce costs significantly.
Zepbound vs. Mounjaro vs. Semaglutide
Now, how do Zepbound and Mounjaro compare to semaglutide, another major player in the weight-loss game? Semaglutide, marketed under brand names like Wegovy and Ozempic, is another one of the popular GLP medications that works similarly to tirzepatide. Let’s talk about the price.
Wegovy, which is designed for weight loss, often carries a higher price tag. According to the manufacturer NovoCare, the list price at the time of writing is $1,349.02 per package [8]. Ozempic, on the other hand, is slightly cheaper at $968.52 per pen [9].
Like Zepbound and Mounjaro, insurance coverage for this medication can be hit-or-miss as well.
Where to Get Zepbound and Mounjaro Online
Don’t want the hassle of visiting a doctor’s clinic in person? A telehealth service like Jack & Jill could be a convenient alternative for you.
Jack & Jill
Jack & Jill is a telehealth platform that specializes in weight loss and ED solutions. It offers monthly subscriptions to both Zepbound and Mounjaro, along with other weight loss medications like Ozempic and generic semaglutide.
You’ll get the chance to have a virtual consultation with the medical team of Jack & Jill, who will prescribe you the appropriate meds given your health history and goals. Although it’s a bit pricey, you can get discounts by signing up for a subscription for three or six months.
Cost
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Zepbound: $1,548 per month
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Mounjaro: $1,425 per month
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Ozempic: $1,300 per month
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Semaglutide: $248 per month
User Reviews
While reviews on third-party platforms are scarce, many verified users wrote on the official Jack & Jill site that its solutions helped them shed pounds and curb their appetite. One customer did mention that he also improved his lifestyle while taking the weight loss medications [10].
>>See if you’re eligible for a Zepbound or Mounjaro prescription at Jack & Jill
Jack & Jill Alternatives: Other Telehealth Services Offering Weight Loss Solutions
Now that we have all the key information down about Zepbound and Mounjaro weight loss medications from Jack & Jill, let’s take a look at some alternatives on the market. Wondering how to ask your doctor for weight loss pills online? Here are other options for telehealth services that offer prescription meds that may level up your weight loss game:
ReflexMD: Semaglutide
ReflexMD is another online telehealth platform that specializes in weight loss solutions like semaglutide. It offers personalized programs that include virtual consultations with licensed physicians, prescriptions, and home delivery of medications.
The process begins with an online health questionnaire, followed by a consultation to discuss your weight loss goals and medical history. Once prescribed, you’ll get medications shipped directly to your door, with ongoing support and regular follow-ups to adjust your treatment plans as needed. The monthly fees are all-inclusive with no hidden costs.
Cost
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Semaglutide: $497 per month (the first month starts at $297)
User Reviews
In their Trustpilot reviews, several users appreciated how ReflexMD made it easier for them to lose weight, while some praised its customer support [11]. On the other hand, a few said they encountered shipping delays [12].
>>Explore ReflexMD’s semaglutide offerings
Strut: Semaglutide
Strut covers a wide range of health solutions, and weight loss is one of them. It could be a practical option if you have several wellness concerns you’d like to address, such as hair loss, sexual health, and skin care.
Its weight loss program includes online doctor’s consultations, follow-up care, and free shipping. The meds are quite affordable, but the telehealth service only offers generic semaglutide and not branded weight loss drugs.
Cost
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Semaglutide lozenges: As low as $149 per month
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Semaglutide injections: $289 per month
User Reviews
Different customers have different opinions of Strut. In r/Semaglutide, for instance, someone mentioned that he shed pounds with the platform’s assistance. On the flip side, some are not yet ready to take the plunge even though they’re curious about Strut [13].
>>Check out semaglutide prices on Strut
Maximus: Tirzepatide and Semaglutide
Maximus features two weight loss solutions. One of them is semaglutide while the other is tirzepatide, the same active ingredient as Zepbound and Mounjaro. The personalized programs are tailored to your individual needs by a doctor who is available to speak to through the platform.
The treatment involves a weekly injection, with dosages adjusted based on your progress and goals. Some Maximus Tribe reviews highlight the additional support it provides, including private coaching and exclusive content to help you preserve lean muscle mass during weight loss.
Cost
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Tirzepatide: Starts at $399 per month
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Weight Loss Protocol Semaglutide: Begins at $249 per month
User Reviews
Many users praised Maximus Tribe on Trustpilot, but most of the reviews focused on its testosterone solutions instead of the weight loss protocols [14]. Nonetheless, there are verified clients on the official Maximus website who claim to have dropped pounds with the help of the platform’s medications [15].
>>Learn more about tirzepatide and semaglutide on Maximus
OTC Weight Loss Solutions
Looking for something a bit less complicated? There are plenty of over-the-counter weight loss pills available that may better fit your needs.
PhenQ
As a natural weight management supplement, PhenQ tackles body fat from multiple angles, like fat burning, appetite suppression, and energy boosting. This supplement takes a comprehensive approach, helping you achieve your weight loss goals through a blend of scientifically backed ingredients.
One of the standout components in PhenQ is a-Lacys Reset, a patented formula combining alpha-lipoic acid, cysteine base, and magnesium. This unique blend has shown small yet significant weight loss in many clinical trials [16].
Another key player is Capsimax powder, which combines capsicum extract, caffeine, piperine, and niacin. Together, these ingredients may improve fat burning by increasing resting energy expenditure (or how many calories you burn while resting) [17]. Plus, it offers free shipping worldwide and a 60-day money-back guarantee.
Cost
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One-month supply: $69.99
User Reviews
Many customers loved how PhenQ has helped them shed excess pounds. One commenter on Reddit said it boosted their metabolism, while another explained that it doesn’t promise overnight results but promotes slow but lasting weight loss [18].
>>Explore how PhenQ promotes weight loss
KetoCharge
Are you following the ketogenic diet? KetoCharge makes it easier for you to enter ketosis, where your body burns fat instead of sugar to produce energy.
This supplement also assists in preventing the signs of keto flu, like tiredness, body aches, and brain fog, which could discourage you from sticking to this diet plan.
The formula has fewer ingredients than the other options in our list. Nevertheless, it does feature BHB salts like magnesium, sodium, and calcium beta-hydroxybutyrate, which may jumpstart the process of ketosis while protecting lean muscle mass [19].
Cost
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One-month supply: $59.99
User Reviews
Some keto dieters agree that KetoCharge comes in handy during the diet period. A Redditor shared on r/weightlossdiets that it helped his friend stay in ketosis but clarified that his buddy only saw results after pairing it with regular workouts as well [20].
>>Find out how KetoCharge supports weight loss
Phen24
Looking for a weight loss supplement that works around the clock to help you lose weight? Phen24 offers two formulas: one for daytime to boost metabolism and energy and another for nighttime to continue fat-burning and curb late-night cravings.
One key ingredient in the daytime formula is guarana extract, which is known for its high caffeine content. It may also help your body burn stored fat and boost your energy [21].
Avoiding stimulants and helping your body burn calories at rest is the nighttime formula’s main focus. The formula includes griffonia extract, which may help you feel full and reduce your late-night snack cravings for unhealthy foods [22].
Cost
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One-month supply: $69.99
User Reviews
A good number of customers approved of Phen24’s comprehensive 24-hour support. For example, a Redditor liked how it supports daytime energy and nighttime metabolism. On the other hand, it’s not the only weight loss supplement he recommended [23]
>>Discover the dual formulas of Phen24
Zepbound vs. Mounjaro: FAQs
Do you have more questions about these weight loss medications? Let’s take a look at the popular questions surrounding this topic.
Is Zepbound the Same as Mounjaro?
Yes, at least in terms of the main compound. Both use the same active ingredient, tirzepatide, but they’re marketed and FDA-approved for different treatments. Zepbound is geared towards weight loss, while Mounjaro is primarily marketed for managing type 2 diabetes.
Can You Switch From Mounjaro to Zepbound?
In most cases, yes! If your focus changes from diabetes control to weight management, your doctor might recommend the switch. You should talk to your healthcare provider first, though.
Is Zepbound Better Than Semaglutide?
It depends on your goals, but ultimately, the active ingredients do similar things.
What Is Comparable to Zepbound?
The Ozempic vs. Wegovy vs. Mounjaro vs. Zepbound debate is an interesting one as they are all worth comparing, each with its unique offering. After all, these weight loss injections offer similar benefits and side effects.
What Is More Expensive, Mounjaro or Zepbound?
As for the Mounjaro vs. Zepbound cost comparison, Zepbound’s list price is more expensive, but only by less than $10 a month. If you get a subscription from Jack & Jill, Zepbound’s monthly cost is higher by $123 than Mounjaro’s.
Can You Take Zepbound and Mounjaro Together?
No, you shouldn’t combine them as they’re the same medication under different names. Doubling up won’t improve the results and could increase the side effects.
Who Makes Zepbound and Mounjaro?
Both are manufactured by Eli Lilly, a pharmaceutical company known for innovative treatments.
What’s the Difference Between Mounjaro and Ozempic?
The key difference is the active ingredient: Mounjaro uses tirzepatide, while Ozempic relies on semaglutide.
Zepbound vs. Mounjaro: Final Thoughts
Choosing between Zepbound and Mounjaro boils down to your health goals, whether it’s managing type 2 diabetes, tackling weight loss, or both. While they’re essentially the same medication, the branding and approval status does matter.
Talk to your doctor, weigh your options, and pick the one that aligns best with your needs. Then, once you’ve figured out which one suits you best, check if you’re eligible for a Mounjaro or Zepbound subscription at Jack & Jill or other telehealth services.
>>Inquire about Zepbound or Mounjaro prescriptions at Jack & Jill
References:
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Bull, S. T., Nuffer, W., & Trujillo, J. M. (2022). Tirzepatide: A novel, first-in-class, dual GIP/GLP-1 receptor agonist. Journal of Diabetes and Its Complications, 36(12), 108332. https://doi.org/10.1016/j.jdiacomp.2022.108332
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Center for Drug Evaluation and Research. (n.d.). Drug trials snapshots: Mounjaro. U.S. Food and Drug Administration. https://www.fda.gov/drugs/drug-approvals-and-databases/drug-trials-snapshots-mounjaro
-
FDA. (n.d.). FDA approves new medication for chronic weight management. U.S. Food and Drug Administration. https://www.fda.gov/news-events/press-announcements/fda-approves-new-medication-chronic-weight-management
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Samuel SM, Varghese E, Kubatka P, Büsselberg D. Tirzepatide-Friend or Foe in Diabetic Cancer Patients? Biomolecules. 2022 Oct 28;12(11):1580. doi: 10.3390/biom12111580. PMID: 36358930; PMCID: PMC9687454.
-
Jastreboff, A. M., Aronne, L. J., Ahmad, N. N., Wharton, S., Connery, L., Alves, B., Kiyosue, A., Zhang, S., Liu, B., Bunck, M. C., Stefanski, A., & SURMOUNT-1 Investigators (2022). Tirzepatide Once Weekly for the Treatment of Obesity. The New England journal of medicine, 387(3), 205–216. https://doi.org/10.1056/NEJMoa2206038
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Mounjaro Cost Information | With or Without Insurance |Mounjaro® (tirzepatide) injection. (n.d.). Pricinginfo.lilly.com. https://pricinginfo.lilly.com/mounjaro
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Zepbound Cost Information | With or Without Insurance | Zepbound® (tirzepatide) injection. (2024). Lilly.com. https://pricinginfo.lilly.com/zepbound
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Wegovy® (semaglutide) injection 2.4 mg List Price & Insurance Coverage Explained | NovoCare®. (n.d.). Www.novocare.com. https://www.novocare.com/obesity/products/wegovy/let-us-help/explaining-list-price.html
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Ozempic® (semaglutide) injection 0.5 mg, 1 mg, 2 mg List Price & Insurance Coverage Explained | NovoCare®. (n.d.). Www.novocare.com. https://www.novocare.com/diabetes/products/ozempic/explaining-list-price.html
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Affordable Weight Loss Customized For You | Jack&Jill. (2025). Jackjill.health. https://jackjill.health/weight-loss
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Thomas Kessler gave ReflexMD 5 stars. Check out the full review… (2025, January 15). Trustpilot. https://www.trustpilot.com/reviews/6786fcc01b935165083ec3aa
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Carolyn Garvie gave ReflexMD 2 stars. Check out the full review… (2025, January 14). Trustpilot. https://www.trustpilot.com/reviews/67866c8fb57a2f4c1671129a
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Reddit – Dive into anything. (2024). Reddit.com. https://www.reddit.com/r/Semaglutide/comments/1cqz25c/strut_health/
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Chris Cockrell gave maximustribe.com 5 stars. Check out the full review… (2025, January 17). Trustpilot. https://www.trustpilot.com/reviews/678a9ce8fb4ee3d05c58d6b6
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“Weight Loss Protocol Semaglutide.” Maximus, www.maximustribe.com/semaglutide-1. Accessed 22 Jan. 2025.
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Kucukgoncu S, Zhou E, Lucas KB, Tek C. Alpha-lipoic acid (ALA) as a supplementation for weight loss: results from a meta-analysis of randomized controlled trials. Obes Rev. 2017 May;18(5):594-601. doi: 10.1111/obr.12528. Epub 2017 Mar 13. PMID: 28295905; PMCID: PMC5523816.
-
Janssens PL, Hursel R, Martens EA, Westerterp-Plantenga MS. Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance. PLoS One. 2013 Jul 2;8(7):e67786. doi: 10.1371/journal.pone.0067786. PMID: 23844093; PMCID: PMC3699483.
-
Reddit – Dive into anything. (2024). Reddit.com. https://www.reddit.com/r/weightlossdiets/comments/19dbr34/my_phenq_review_2024/
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Buga, A., Kackley, M. L., Crabtree, C. D., Sapper, T. N., Mccabe, L., Fell, B., LaFountain, R. A., Hyde, P. N., Martini, E. R., Bowman, J., Pan, Y., Scandling, D., Brownlow, M. L., O’Connor, A., Simonetti, O. P., Kraemer, W. J., & Volek, J. S. (2021). The Effects of a 6-Week Controlled, Hypocaloric Ketogenic Diet, With and Without Exogenous Ketone Salts, on Body Composition Responses. Frontiers in Nutrition, 8. https://doi.org/10.3389/fnut.2021.618520
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Reddit – Dive into anything. (2025). Reddit.com. https://www.reddit.com/r/weightlossdiets/comments/1hxwp80/ketocharge_review_is_it_worth_trying_in_2025/
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Halford, JCG. “Acute effects of a herb extract formulation and inulin fibre on appetite, energy intake and food choice.” PubMed, https://pubmed.ncbi.nlm.nih.gov/23207186/.
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Rondanelli, M., Opizzi, A., Faliva, M., Bucci, M., & Perna, S. (2012). Relationship between the absorption of 5-hydroxytryptophan from an integrated diet, by means of Griffonia simplicifolia extract, and the effect on satiety in overweight females after oral spray administration. Eating and Weight Disorders: EWD, 17(1), e22-28. https://doi.org/10.3275/8165
This article appears in Jan 31 – Feb 13, 2025.