Liver Detox: Best Supplements for Cleansing Toxins From Your Body | 2025

Your body has an amazing system of detoxification pathways set up to clear metabolic waste products, process the food you digest, and deal with ingested toxins. However, these systems can be overwhelmed by your diet, environment, and other physiological factors.

If you feel like your detoxification systems are being pushed past their limits, you may benefit from a liver cleanse product. But how does it work, and which are the best liver detox brands today? We found some liver supplements could be helpful, which we will discuss later on.

What Is a Liver Detox?

A liver detox is a program or product that may help boost your ability to remove toxins from your body or help your liver repair itself from years of being overburdened. Some products and ingredients are known to be highly beneficial, such as nutrients required for detoxification or chelation for severe cases.

Although the liver and kidneys process and remove toxins, there are thousands of artificial pollutants in the world that they may not succeed in getting rid of.

For example, persistent organic pollutants, volatile organic compounds, pesticides, heavy metals released from fossil fuel use, and more can overburden the liver. Moreover, a diet rich in processed foods and excessive alcohol consumption could make matters worse [1].

Is a Liver Detox Safe?

Legitimate liver detox supplements are generally safe, and they work by supporting your body’s natural detoxification pathways. Those with no evidence or more heavy-handed methods, such as chelation, can have side effects, such as reducing levels of beneficial minerals. Additionally, poor-quality liver detox supplements might be contaminated with pollutants or drugs [2].

To find a safe liver cleanse product, consider the following factors:

• Evidence-backed ingredients such as milk thistle (preferably standardized to a certain percentage of silymarin), n-acetyl cysteine, B vitamins, bitter herbs such as yarrow, and bile acids like tauroursodeoxycholic acid (TUDCA).

• No unrealistic claims, such as a guarantee that severe issues can be reversed with oral, over-the-counter products.

• Mentions of third-party testing or production in FDA-registered, GMP-certified facilities.

• Positive user reviews and no reports of legal action against the product in the past.

• Money-back guarantees if the product does not work.

Can a Liver Cleanse Help You Heal From Overconsumption of Alcohol or Unhealthy Food?

Consuming too much alcohol and unhealthy foods can lead to fatty liver disease. When considering how to cleanse your liver from years of unhealthy habits, start with improving your diet, avoiding toxins, and exercising regularly [3].

However, some supplements claim to help protect your liver against alcoholic and non-alcoholic fatty liver disease (NAFLD). One of the best ingredients for a fatty liver detox is milk thistle (silybum marianum), particularly when it’s standardized to contain a certain amount of silymarin.

One lab study revealed 61 liver-protective processes, with possible effects including reduced blood levels of liver enzymes and cholesterol. Additionally, liver enzymes are released into the blood after cell damage [4].

Other ingredients that may help include turmeric, which may reduce liver fat by up to 79%. Green tea, especially as a standardized extract, may also reduce liver fat and inflammation. Panax ginseng (a.k.a. Korean ginseng) which is often used in testosterone boosters seems to lower liver enzymes and even scarring scores [2].

Can a Liver Detox Help Prevent Liver Disease?

Certain ingredients have shown benefits in addressing liver disease and overall health. However, we do not advise that you rely on liver detox drinks or capsules alone to avoid these conditions. A good diet, an active lifestyle, and avoiding sources of environmental toxins should be the top priorities.

Ways To Prevent Liver Disease

The first and most important step in preventing liver disease is to avoid its causes. If you want to drink alcohol, enjoy it in moderation and consider certain hangover relief supplements that aid in clearing your body of alcohol. Never take recreational drugs, and always review prescription medication with your doctor to ensure that you are not taking more than necessary.

Obesity is a major risk factor for liver disease, especially non-alcoholic fatty liver disease. If dieting doesn’t work, you may need interventions such as personalized, one-on-one nutritional and exercise support alongside medication.

A liver detox diet should include a variety of foods rich in antioxidants and essential nutrients. Cruciferous vegetables such as broccoli and cabbage, leafy greens, citrus fruits, oily fish, berries, pomegranates, nuts, seeds, beans, and herbs and spices like turmeric and garlic can all help out [5].

Can a Liver Detox Help With Weight Loss?

A liver and kidney detox may help with weight loss. Some synthetic chemicals, known as endocrine disruptors, may affect hormone levels and functions. Some are called obesogens, meaning their effects on hormones and metabolism cause fat accumulation. These include certain phthalates and bisphenol A [6].

Persistent Organic Pollutants (POPs), including dioxins, flame retardants, and polychlorinated biphenyls, not only affect energy metabolism but are also stored in fat tissue. Weight loss causes them to be released, so they can get in the way of your goals if they aren’t quickly removed [1].

Fatty Liver and Ways To Prevent It

Fatty liver disease is primarily a metabolic, lifestyle-induced condition. As fat accumulates in the liver and inflammation worsens, damaged liver cells can lose their ability to work and may even be replaced with scar tissue [4]. It’s possible to prevent and at least partially reverse fatty liver disease before scarring appears.

If you are overweight or obese, common recommendations involve losing 5-10% of your body weight in six months. At least 30 minutes per day of brisk walking or a similar exercise five days each week is also advisable [4]. Additionally, you must avoid substances with known toxic effects on the liver, such as acetaminophen, rifampicin, tetracycline, and alcohol.

As for what to eat, a Mediterranean diet rich in vegetables, whole grains, fruit, nuts, fish, other lean protein, and herbs and spices may be ideal [3]. To make your own liver detox juice, you can use berries, citrus fruits, or both alongside turmeric or green tea powder [5].

Can Liver Detox Supplements Help?

Unfortunately, many products make questionable claims with headlines such as “How to detox your liver in 3 days.” Thankfully, some supplements contain evidence-backed ingredients and do not need to oversell themselves.

Products that are most likely to be effective include ingredients such as n-acetyl cysteine and milk thistle extracts. These are typically given in high doses intravenously for severe liver toxicity. Some oral supplements use them in smaller doses but may possibly work for generally healthy people who want to turn over a new leaf.

Best Liver Detox Supplements

Supplementation may help when searching for ways to cleanse your liver. Oweli, Akasha Naturals, and Axe & Sledge offer some of the best supplements to support your liver health.

1. Oweli Liver Detox

Oweli Liver Detox is one of the best liver detox supplements on the market. It contains ingredients such as milk thistle, zinc, beetroot, artichoke, dandelion, and jujube extract. Milk thistle is well-known for its ability to protect liver cells in cases of acute poisoning. In fact, a concentrated version of one of its components is used in hospitals [4].

Some ingredients can stimulate bile flow while protecting the liver in their own ways. For example, yarrow has anti-inflammatory effects by preventing immune cells from breaking down connective tissue proteins. Aside from reducing the number of immune cells around to trigger damaging inflammation, it increases bile flow to help flush out metabolized toxins [7].

Dosage

Oweli’s Liver Detox has a simple dosage of two capsules daily. We recommend taking it for one to three months, and if your exposure to harmful substances is heavier, you can cycle on again.

Prices

• One month: $49.99 (one-time purchase) or $39.99 (subscription)

• Three months: $119.97 (single purchase) or $95.98 (for subscribers)

• Six months: $179.94 (one-time purchase) or $143.95 (subscription)

In addition to the 20% discount for subscribers, there’s also a 100-day money-back guarantee if you’re not happy with the product.

User Feedback

Many customers have a positive opinion of Oweli Liver Detox. One of them is u/mvspharma_virudol, who described it on r/Supplements as one of the top liver supplements. However, it’s not the only product this Redditor recommended, and names of other alternatives were thrown in the air.

2. Akasha Naturals Liver Detox

Akasha Naturals focuses on the power of milk thistle, with silymarin standardized to 80 mg. Silymarin is used to protect against amanita phalloides poisoning in hospitals and may reduce mortality rates in alcoholic cirrhosis [2].

Other ingredients include Oregon grape, yellow dock, burdock, and dandelion root. Oregon grape is a source of berberine, which research suggests can protect against liver injury even during chemotherapy and radiation in higher doses [8]. By reducing inflammation and oxidative stress while improving energy production, berberine can help your liver cells do their job better.

Dosage

You only need to take one capsule daily.

Prices

• One bottle: $37.75 for 60 servings

If you change your mind, Akasha Naturals has a 30-day refund guarantee, but only for unopened products.

User Feedback

Some users saw a difference after using Liver Detox. On the Akasha Naturals website, verified buyer Tushar W. said it helped him maintain the correct liver enzyme levels for a few years [9]. On the flip side, it’s challenging to find third-party reviews for this supplement that have more balanced reviews

3. Axe & Sledge Liver+

Axe & Sledge Liver+ contains several powerful antioxidants that can improve liver detoxification. These include milk thistle, n-acetyl cysteine, and astragin.

N-acetyl cysteine can be a powerful liver protector thanks to its antioxidant effects. These may help you fight stress caused by processing environmental toxins and metabolic wastes.

High doses given intravenously are an established treatment for liver failure caused by acetaminophen (Tylenol). Better yet, research shows that n-acetylcysteine treatment improved survival rates from 47% to 72% after severe liver damage from drugs, toxins, and hepatitis E [10].

Another ingredient in Liver+ is TUDCA, a type of bile acid now ethically made in labs. TUDCA can reduce liver fat buildup and increase bile production, helping you flush out waste products. It may even support the health of your gut bacteria and improve the integrity of your intestinal wall. This could reduce your body’s toxic burden by keeping out some harmful substances [11].

Dosage

Each daily dose consists of four capsules; you can take them at a time that suits you best.

Prices

• One month: $54.99

User Feedback

Several customers appreciate Liver+ by Axe & Sledge. On Amazon, Ryan liked how it combined liver-supporting ingredients in one product. Nevertheless, he also felt that the supplement was a little too pricey [12].

4. Apollon Liver Lover

Apollon Liver Lover combines n-acetyl cysteine, milk thistle, and TUDCA with reishi mushroom extract. Together, these ingredients may protect your liver while detoxifying substances, support its regenerative capacity, and stimulate bile flow.

Reishi (ganoderma lucidum) extract has shown many potential benefits in the lab as a liver and kidney detox ingredient. Some of its effects include improved liver cell survival, protective antioxidant effects, less inflammation, improved fat metabolism, and reduced fatty acid buildup. What’s more, reishi may support healthy gut bacteria populations [13].

Dosage

Take six capsules of this liver supplement every day.

Prices

• One month: $54.95

User Feedback

Several users appreciate the benefits of Liver Lover. On the Apollon Nutrition website, verified buyer David F. shared that it improved his energy levels and quality of sleep while helping keep his sugar levels down [14]. Unfortunately, third-party reviews of this supplement are hard to find, and users may need to ask friends, family, or Reddit users who may have tried it to get a more balanced perspective of the product’s efficacy.

FAQs About Liver Detox

Here are some common questions people have when searching for an effective liver cleanse.

How Do You Flush Out Your Liver?

Certain ingredients in the top liver cleanse products can stimulate bile flow, allowing metabolized toxins to be flushed out instead of being at risk for reabsorption. These include yarrow and artichoke [7].

What Is the Best Drink To Flush Your Liver?

Although none of the supplements in our review are available as drinks, you can find affordable liquid supplements with caffeine and B vitamins. These may act as liver detox drinks by stimulating some detoxification pathways. Moreover, caffeine is also a diuretic.

How Can I Clean My Liver in 7 Days?

To be realistic, it usually takes more than seven days to cleanse your liver. Yet, you can start the process by taking supplements with ingredients that support detoxification. Take these alongside a healthy diet while avoiding harmful factors such as excess alcohol and drug use.

What Is the Fastest Way To Repair Your Liver?

Wondering what supplements you should use to detox liver fast? The fastest way to repair your liver may be a relatively high dose of n-acetyl cysteine, milk thistle, or a combination of both [10] [4]. However, a long-term diet and lifestyle changes should be your top priority to maintain a healthy liver.

How To Tell if Your Liver Is Struggling?

If you have NAFLD, you may have symptoms such as high blood sugar levels, fatigue, indigestion, high blood pressure, and excess body fat. Severe cases of liver damage cause a yellowed complexion (jaundice), which may require immediate medical attention [15].

What Is the Best Vitamin for Liver Repair?

A range of vitamins support liver detoxification and repair, including vitamins A, B6, and B9 (folate) [16]. How much time does it take for vitamins to take effect? It depends on each user and various factors, like the condition of their liver and their lifestyle.

Final Thoughts on Liver Detox

If you want to detox your liver fast, there are ways to speed up the healing process. This may help prevent NAFLD and other issues after years of unhealthy habits and environmental exposures.

The best liver supplements contain antioxidant ingredients, which help protect the liver while it does its job. These may also feature natural ingredients that stimulate bile production or act as essential nutrients for detoxification pathways.

References

1. Sears, Margaret E, and Stephen J Genuis. “Environmental determinants of chronic disease and medical approaches: recognition, avoidance, supportive therapy, and detoxification.” Journal of environmental and public health vol. 2012 (2012): 356798. doi:10.1155/2012/356798

2. Mancak, Methiye et al. “Evidence-based herbal treatments in liver diseases.” Hepatology forum vol. 5,1 50-60. 16 Jan. 2024, doi:10.14744/hf.2022.2022.0052

3. Houttu, Veera et al. “Dietary Interventions in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis.” Frontiers in nutrition vol. 8 716783. 22 Jul. 2021, doi:10.3389/fnut.2021.716783

4. Jiang, Guoyan et al. “Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification.” Bioengineered vol. 13,3 (2022): 5216-5235. doi:10.1080/21655979.2022.2037374

5. Hodges, Romilly E, and Deanna M Minich. “Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application.” Journal of nutrition and metabolism vol. 2015 (2015): 760689. doi:10.1155/2015/760689

6. Kladnicka, Iva et al. “Obesogens in Foods.” Biomolecules vol. 12,5 680. 9 May. 2022, doi:10.3390/biom12050680

7. Benedek, Birgit, and Brigitte Kopp. “Achillea millefolium L. s.l. revisited: recent findings confirm the traditional use.” Wiener medizinische Wochenschrift (1946) vol. 157,13-14 (2007): 312-4. doi:10.1007/s10354-007-0431-9

8. Song, Danyang et al. “Biological properties and clinical applications of berberine.” Frontiers of medicine vol. 14,5 (2020): 564-582. doi:10.1007/s11684-019-0724-6

9. Liver Detox. (2025). Akasha Naturals. https://akashanaturals.com/collections/akasha-naturals/products/liver-detox-60-veggie-softgels

10. Nabi, Tauseef et al. “Role of N-acetylcysteine treatment in non-acetaminophen-induced acute liver failure: A prospective study.” Saudi journal of gastroenterology: official journal of the Saudi Gastroenterology Association vol. 23,3 (2017): 169-175. doi:10.4103/1319-3767.207711

11. Wang, Huan et al. “Tauroursodeoxycholic Acid Improves Nonalcoholic Fatty Liver Disease by Regulating Gut Microbiota and Bile Acid Metabolism.” Journal of agricultural and food chemistry vol. 72,36 (2024): 20194-20210. doi:10.1021/acs.jafc.4c04630

12. Check out this Amazon review of Axe & Sledge Liver Supplement with TUDCA, NAC, and Milk Thistle. (2025). Amazon.com. https://www.amazon.com/gp/customer-reviews/R2LJ6TXKDDZ6VY/ref=cm_cr_dp_d_rvw_ttl?ie=UTF8&ASIN=B0D1RKDN65

13. Ahmad, Md Faruque et al. “Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action.” Nutrients vol. 15,8 1874. 13 Apr. 2023, doi:10.3390/nu15081874

14. Liver Lover – Daily Liver Support & Protection. (2025). Apollon Nutrition. https://www.apollonnutrition.com/products/liver-lover-daily-liver-support-protection

15. Kudaravalli, P., & John, S. (2023). Nonalcoholic fatty liver. PubMed; StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK541033/

16. Abe, R. A. M., Masroor, A., Khorochkov, A., Prieto, J., Singh, K. B., Nnadozie, M. C., Abdal, M., Shrestha, N., & Mohammed, L. (2021). The Role of Vitamins in Non-Alcoholic Fatty Liver Disease: A Systematic Review. Cureus, 13(8). https://doi.org/10.7759/cureus.16855

This article appears in Feb 28 – Mar 6, 2025.